A businessman sinks $200 million into a special project to help fight Alzheimer's disease. As part of this project, medical biologist Susan McAlester rather naughtily figures out a way to genetically enlarge shark brains, so that disease-battling enzymes can be harvested. However, the shark subjects become super smart and decide they don't much like being cooped up in pens and being stabbed with hypodermics, so they figure a way to break out and make for the open sea... 好厨子可以战胜一切～。水深火热。当鲨鱼学会了复仇。鲨鱼聪明了会发生什么？。从《深海狂鲨》看怪物灾难片的十大典型特征。其实这片儿就一黑色幽默。一部非常出色的灾难片，谁会葬身鱼腹，根本猜不到。怀念当年大鲨鱼。。还不错的灾难片。从科学家的角度讲我认为苏珊没有任何问题。 生化制药厂的老板Franklin（塞缪尔·杰克逊 Samuel L. Jackson 饰）提供大量资金供让Susan McAlester博士（萨弗蓉·布罗斯 Saffron Burrows 饰）研究抗老年痴呆症的药物。Susan和研究小组在设备精良的海底研究中心，提取鲨鱼脑中蛋白质，注入坏死的人类脑细胞。为了可以提取到萃取更多的鲨鱼脑蛋白，Susan也同时加大了鲨鱼们的脑容量。这一举动让本来作为试验品的鲨鱼们变得更为强壮和聪明。鲨鱼专家Carter（托马斯·简 Thomas Jane 饰）因和鲨鱼们朝夕相处时发现了鲨鱼们的异样，并向Susan提出了警告，却得到了Susan的无视。终于，在最后一次验中，那些曾经沦为人类试验品的凶残鲨鱼们向人类展开报复……
